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KMID : 0895820090190020001
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Journal of Oriental Rehabilitation Medicine
2009 Volume.19 No. 2 p.1 ~ p.25
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Effects of Yanghyuljanggeungunbo-tang(Yangxuezhuangjinjianbu -tang ) and Electrical Acupuncture on the Spinal Nerve Injury and the Motor Function
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Sul Jae-Uk
Chu Min-Kyu
Kim Sun-Jong
Choi Jin-Bong
Shin Mi-Suk
Kim Soo-Ik
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Abstract
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Objectives:
ThepurposeofthisstudywastoinvestigatetheeffectsofYanghyuljanggeungunbo-tang(Yangxuezhuangjinjianbu-tang,YGKT)andelectricalacupuncture treatmentinspinalcordinjury(SCI)-inducedrats.
Methods:
Thesubjectsweredividedinto5groups;Normal,Control-notreatmentafterSCI,ExperimentalⅠ(Exp.Ⅰ)-takenwithYGKT500㎎/㎏ 0.5㎖ daily afterSCI.ExperimentalⅡ(Exp.Ⅱ)-takenwithelectricalacupunctureafterSCIandExperimentalⅢ(Exp.Ⅲ)-takenwithYGKT500㎎/㎏ 0.5㎖ and electricalacupunctureafterSCI.Aftereachoperation,thepresentauthorobservedcytologicalchanges,themotorbehaviorrecoveryandnerve regenerationbyanalysisofthemotorbehaviortests,EMG,hematological (AST,ALT,WBC),histologicalandimmunologicalchanges.Ratsweretested byMotorbehaviortestat1st,3rd,7th,14thand21stday.
Results:
1.AlltheexperimentalgroupswereimprovedcomparedwithcontrolgroupinthemotorbehaviortestsincludingTarlovtest,Basso-Beattle-Bresnahan locomotorratingscale,modifiedinclinedplanetest,openfieldtest,gridwalktestandnarrow beam test.EspeciallyExp.Ⅲ wassignificantly improvedamongothergroups.
2.InEMGtest,HandM waveweresignificantlyincreasedinExp.Ⅲ.
3.AlltheexperimentalgroupsweresignificantlydecreasedcomparedwithcontrolgroupinAST,ALTandWBC.
4.NGF,BDNFandTrkBofspinalcordgraymatterinalltheexperimentalgroupswereincreasedcomparedwithcontrolgroup.Especially,Exp.Ⅲ wasmoreeffective.
5.Inhistologicalobservations,musclecontractionanddenaturationofgastrocnemiusmuscleofalltheexperimentalgroupswereinhibited.Especially,thoseofExp.Ⅲ wasmoreeffective.Ontheobservationsofliverandkidney,cellatrophyandapoptosisofalltheexperimentalgroupswere
decreasedcomparedwithcontrolgroup.Especially,thoseofExp.Ⅲ wasmoreeffective.
Conclusions:
ItcanbesuggestedthatYGKTandelectricalacupuncturemayimprovemotorbehavior,EMG,hematological,histologicalandimmunologicalfindingsin SCI- inducedrats.Especially,combinationofthesetwotreatmentswillbesomewhatbetterinspinalnerverecoveryandmotorfunctionimprovement.
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KEYWORD
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:Spinalcordinjury, Yanghyuljanggeungunbo-tang(Yangxuezhuangjinjianbu-tang), Electricalacupuncture, Motorrecovery, Nervegrowthfactor
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